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René Descartes was a central figure in the scientific revolution of the 17th century. In his Discourse on Method he outlined the contrast between mathematics and experimental sciences, and the extent to which each one can achieve certainty. Drawing on his own work in geometry, optics, astronomy and physiology, Descartes developed the hypothetical method that characterizes modern science, and this soon came to replace the traditional techniques derived from Aristotle.

By calling everything into doubt, Descartes laid the foundations of modern philosophy. With the celebrated words "I think therefore I am," his compelling argument swept aside ancient and medieval traditions. He deduced that human beings consist of minds and bodies; that these are totally distinct "substances"; that God exists and that He ensures we can trust the evidence of our senses.