In this episode, we are diving into a topic that—quite literally—gets people's blood pumping! We are looking at the brand new, 2025 American Heart Association and American College of Cardiology Hypertension Guidelines (AKA The PREVENT Standard), and to help us decode this massive document, we've got Dante DiMatteo (PharmD) in the hot seat.

The medical community is calling this a "watershed moment." We're moving from just looking at a number on a cuff to understanding the whole system—heart, kidneys, and metabolism. So what changed? What does it mean for you and your health? Generation Health explains it all!

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Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:24 - Show Intro
01:22 - New Blood Pressure Guidelines
02:43 - What has been updated?
04:59 - How is kidney function related to blood pressure?
06:44 - Mechanisms of blood pressure and cognitive decline
08:58 - What are healthy blood pressure readings?
10:08 - How is someone diagnosed for high BP?
15:22 - What has changed?
19:44 - Changes to pharmacology
25:04 - Other pharmacology changes
26:28 - Changes to lifestyle modifications
32:23 - Show Outro

SHOW NOTES:
1) 2025 Guideline For High Blood Pressure in Adults (JACC Journals) - https://tinyurl.com/2hudprv5
2) Updated Hypertension Guidelines (Pharmacy Times) - https://tinyurl.com/mrxn7tkt
3) About PREVENT Risk Calculator (AHA) - https://tinyurl.com/mspjtyh2
4) PREVENT Online Calculator (heart.org) - https://tinyurl.com/3f7wxz6r

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Lithium appears to contribute to cognitive preservation during aging and a new study looks at what happens to the brain when lithium is deficient, possibly leading to Alzheimer's disease. Better still, it looks like increasing the brain's lithium levels may actually reverse the effects. Lithium orotate is getting a glow-up and we're excited for it!

Also, the "magic pill" may finally be real. Wegovy, one of the popular new GLP-1 weight-loss medications is now available as a daily oral prescription! How does it differ from injections and how is dosing affected? Is it cheaper than the shots?

We love questions! Comment below or email us: questions@askjoedimatteo.com

ALL PRODUCTS: https://www.AskJoeDimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:29 - Show Intro
01:38 - Study: Alzheimer's and Lithium Deficiency
02:52 - What is Lithium?
04:26 - What was studied?
06:47 - Details about the animal study
08:55 - How is lithium protecting the brain?
12:22 - Lithium in drinking water
13:28 - Takeaways
16:21 - Wegovy Pill
17:31 - Details of the Wegovy Pill
19:45 - Do you need to titrate up?
20:36 - If it's working, do you need to take more?
22:49 - What's the difference between the pill and injectable?
23:59 - Differences in cost
25:13 - Other points
27:43 - Dietary suggestions while on Wegovy
29:54 - Show outro

SHOW NOTES:
1) Lithium and Alzheimer's (Nature) - https://tinyurl.com/aywhpx2h
2) Lithium deficiency and onset of Alzheimers (NIH) - https://tinyurl.com/y2dxvmdf
3) New GLP-1 Pill Compared to Shot (Web MD) - https://tinyurl.com/mt2mvtpv
4) Wegovy Pill in High Demand (NBC News) - https://tinyurl.com/ktb84h54
5) Wegovy pill now available across America (PR Newswire) - https://tinyurl.com/2t6uda9w

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

At the top of the year, U.S. Department of Health and Human Services Secretary Robert F. Kennedy, Jr. and U.S. Department of Agriculture Secretary Brooke Rollins released the Dietary Guidelines for Americans, 2025–2030, the most significant reset of federal nutrition policy in decades. Emphasizing "real food," the food pyramid we grew up with has essentially been turned upside down. Dante DiMatteo (PharmD) breaks down the changes: What's good, what's bad and what families should take away from this messy government food fight.

We love questions! Comment below or email us: questions@askjoedimatteo.com

ALL PRODUCTS: https://www.AskJoeDimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:26 - Show Intro
01:15 - New dietary guidelines
02:41 - What does this update affect?
05:18 - Why is this a "hostile takeover?"
12:12 - Specifics of the new guidelines
12:23 - Changes to Protein
17:07 - Changes to Fat
20:57 - The paradox that's occurring
23:32 - What the guideline authors are focused on
28:29 - Biomarker-dependent decision making
35:48 - Carbohydrate/Insulin Model
41:10 - International Reaction to these changes
42:19 - Blue zones
44:30 - Takeaways
45:35 - Show Outro

SHOW NOTES:
1) Official Gov't Site - https://realfood.gov/
2) The Scientific Foundation for the Dietary Guidelines (CDN) - https://tinyurl.com/586crtx3
3) Anabolic Resistance of Muscle Protein Turnover (NIH) - https://tinyurl.com/mvxp9xy7
4) Moderating "the great debate" (NIH) - https://tinyurl.com/4dhtadtb
5) Carbohydrate-insulin model (Royal Society) - https://tinyurl.com/mwa6m7cf
6) Historic Reset of U.S. Nutrition Policy (USDA) - https://tinyurl.com/64wxzt8k

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.