Welcome to episode no. 18 (April 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the April 2024 issue of Diabetes Care. Notably, this episode is a more expansive journey than usual. Dive in at your own pace—segment by segment— or all at once. You can find time stamps for each segment in the notes below. Mike and Alice begin the show by announcing that the April episode will be unlike any episode of Diabetes Care “On Air” that they’ve done. This month, they focus on a Special Collection of articles in the April issue of Diabetes Care. This collection features 10 articles from the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) as well as a commentary on these articles. The full collection is openly accessible at https://diabetesjournals.org/collection/2066/Reports-from-the-GRADE-Study. 2:06: Mike and Alice begin the deep dive into the GRADE articles by bringing in David M. Nathan, chair of the steering committee for the GRADE study. They are then joined by Jennifer B. Green, a member of the GRADE Research Group and an associate editor of Diabetes Care. 9:56: After David M. Nathan and Jennifer B. Green give an overview and synopsis of the collection of GRADE articles, Alice brings in Matthew C. Riddle, former editor in chief of Diabetes Care and author of a commentary on the GRADE articles, to get his general impression of and insights into the GRADE collection. Dr. Riddle’s commentary on the GRADE collection is openly available at https://doi.org/10.2337/dci24-0008. As the discussion continues, the speakers touch on each of the 10 articles of the Special Collection in the April issue of Diabetes Care. The following is a list of all the articles in the collection as well as the commentary, along with links to where these articles can be found (all are openly available). Riddle. Individualizing treatment of type 2 diabetes after metformin: more insights from GRADE. https://doi.org/10.2337/dci24-0008 Gonzalez et al. Differential effects of type 2 diabetes treatment regimens on diabetes distress and depressive symptoms in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-2459 Garvey et al. Association of baseline factors with glycemic outcomes in GRADE: a comparative effectiveness randomized clinical trial. https://doi.org/10.2337/dc23-1782 Banerji et al. Mortality in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-1356 Cherrington et al. Does emotional distress predict worse glycemic control over time? Results from the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-0642Hoogendoorn et al. Emotional distress predicts reduced type 2 diabetes treatment adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-1401Rasouli et al. Longitudinal effects of glucose-lowering medications on β-cell responses and insulin sensitivity in type 2 diabetes: the GRADE randomized clinical trial. https://doi.org/10.2337/dc23-1070Kirkman et al. Comparative effects of randomized second-line therapy for type 2 diabetes on a composite outcome incorporating glycemic control, body weight, and hypoglycemia: an analysis of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-1332Utzschneider et al. Impact of insulin sensitivity and β-cell function over time on glycemic outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): differential treatment effects of dual therapy. https://doi.org/10.2337/dc23-1059Cherrington et al. Impact of glucose-lowering medications on health-related quality of life in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-1648Hollander et al. The use of rescue insulin in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-0516 42:50: Alice directs our attention to another kind of special article available in Diabetes Care, a Profile in Progress on none other than Dr. David M. Nathan. Alice chats with the author of the Profile, Deborah Wexler. Her piece, which Alice notes is “beautifully written,” is openly available at https://doi.org/10.2337/dci23-0095. 48:14: Mike and Alice are once again joined by David M. Nathan, this time for a discussion of his remarkable and extensive career as well as his dedication to advancing the understanding and treatment of diabetes. 1:10:00: In the “Diabetes Care Rapid Exchange,”...
