Episodes

  • Name Bias Delays STEMI Diagnosis 02/24/26

    Name Bias Delays STEMI Diagnosis 02/24/26
    Feb 24 2026
    Welcome to Cardiology Today – Recorded February 24, 2026. This episode summarizes 5 key cardiology studies on topics like Healthcare disparities and Heart failure. Key takeaway: Name Bias Delays STEMI Diagnosis. Article Links: Article 1: Benefit of early initiation of disease-modifying therapy in community-based patients with suspected heart failure. (European heart journal) Article 2: Aortic Insufficiency Progression in Patients with Left Ventricular Assist Devices and Prior Impella Support. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Longitudinal Trends and Contemporary Outcomes of Combined Heart-Lung Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Identification of a Highly Functional Effector CD8+ T Cell Program after Transplantation in Mice and Humans. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 5: Impact of name-based implicit bias on time to diagnosis and outcomes in ST-elevation myocardial infarction. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/name-bias-delays-stemi-diagnosis-02-24-26/ Featured Articles Article 1: Benefit of early initiation of disease-modifying therapy in community-based patients with suspected heart failure. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40879671 Summary: The study concluded that initiating heart failure therapies when an elevated N-terminal pro-B-type natriuretic peptide level is detected in community-based patients with suspected heart failure may reduce the risk of early adverse outcomes. The analysis suggested a potential benefit from the early initiation of a sodium-glucose cotransporter two inhibitor and/or a mineralocorticoid receptor antagonist in these patients. This therapeutic approach applies to individuals with suspected heart failure who also have pre-existing non-heart failure related indications. The findings underscore the importance of prompt pharmacological intervention in managing early stages of heart failure. Article 2: Aortic Insufficiency Progression in Patients with Left Ventricular Assist Devices and Prior Impella Support. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41730484 Summary: The study addressed a critical clinical concern regarding the incidence and risk factors for aortic insufficiency in patients receiving mechanical circulatory support. It focused on individuals who received Impella percutaneous temporary left ventricular assist devices, those with Impella followed by durable left ventricular assist devices, and those with durable left ventricular assist devices alone. Understanding aortic insufficiency progression is crucial for managing patients supported by these devices, as its incidence and specific risk factors have remained unclear in this population. This research highlighted the need for clarity regarding distinct clinical pathways and outcomes in these complex patient groups. Article 3: Longitudinal Trends and Contemporary Outcomes of Combined Heart-Lung Transplantation. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41730483 Summary: The study found that combined heart-lung transplants in the United States experienced a gradual decline, but then showed a significant rise in procedures since 2014, particularly among adults. This shift represents an important change in the landscape of thoracic organ transplantation. Understanding these evolving longitudinal trends is critical for clinicians managing patients awaiting or undergoing this complex procedure. The research provides key insights into the contemporary patterns of combined heart-lung transplantation. Article 4: Identification of a Highly Functional Effector CD8+ T Cell Program after Transplantation in Mice and Humans. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41730451 Summary: The study identified a highly functional effector C.D.8 positive T cell program crucial for post-transplantation immune responses in both mice and humans. Researchers found that agonism of the C.D.43 1B11 receptor in vitro induced C.D.8 positive T cell proliferation even with sub-threshold antigen stimulation. In vivo, C.D.43 1B11 agonism successfully overcame costimulation-blockade induced tolerance and significantly enhanced C.D.8 positive T cell cytokine ...
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  • Diabetes Ups Myocarditis Heart Failure Risk 02/23/26

    Diabetes Ups Myocarditis Heart Failure Risk 02/23/26
    Feb 23 2026
    Welcome to Cardiology Today – Recorded February 23, 2026. This episode summarizes 5 key cardiology studies on topics like antiplatelet therapy and longitudinal study. Key takeaway: Diabetes Ups Myocarditis Heart Failure Risk. Article Links: Article 1: Elevated Activin-A serum levels in patients with acute peripartum cardiomyopathy and during left ventricular recovery. (ESC heart failure) Article 2: Diabetes Increases the Risk of Heart Failure in Myocarditis: A Propensity-Matched Nationwide Database Analysis. (ESC heart failure) Article 3: Nomogram Model for Predicting 90-Day Excellent Outcome in Patients With Acute Vertebrobasilar Artery Occlusion Undergoing Endovascular Thrombectomy. (Journal of the American Heart Association) Article 4: Insomnia and Incident Cardiovascular Disease in US Hispanic/Latino Adults: Results From HCHS/SOL. (Journal of the American Heart Association) Article 5: Safety and Efficacy of Early Aspirin Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT): Rationale and Design of a Multicenter, Randomized, Placebo-Controlled Clinical Trial. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/diabetes-ups-myocarditis-heart-failure-risk-02-23-26/ Featured Articles Article 1: Elevated Activin-A serum levels in patients with acute peripartum cardiomyopathy and during left ventricular recovery. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41728898 Summary: This study analyzed Activin-A serum levels in patients from the German Peripartum Cardiomyopathy registry both at acute diagnosis and during Left Ventricular recovery. It found that elevated circulating levels of Activin-A, a senescence-associated secretory phenotype factor, correlated with heart failure severity in acute Peripartum Cardiomyopathy patients at baseline. The investigation detailed the trajectory of Activin-A serum levels throughout the course of Left Ventricular functional recovery. This analysis highlights Activin-A as a potential biomarker relevant to the pathophysiology and recovery assessment in Peripartum Cardiomyopathy. Article 2: Diabetes Increases the Risk of Heart Failure in Myocarditis: A Propensity-Matched Nationwide Database Analysis. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41728893 Summary: This propensity-matched nationwide database analysis found that diabetes significantly increased the risk of heart failure in patients hospitalized for myocarditis. The study reported that diabetes impacted both in-hospital and long-term outcomes in this patient group. Patients discharged alive were followed for a calendar year, demonstrating the sustained effect of diabetes on subsequent cardiac events. This analysis establishes diabetes as a critical comorbidity that exacerbates adverse outcomes in myocarditis. Article 3: Nomogram Model for Predicting 90-Day Excellent Outcome in Patients With Acute Vertebrobasilar Artery Occlusion Undergoing Endovascular Thrombectomy. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717945 Summary: This study developed and externally validated a nomogram model designed to predict 90-day excellent functional outcomes in patients with acute vertebrobasilar artery occlusion. The nomogram provides a crucial tool for patient selection in endovascular thrombectomy, a procedure proven effective for this condition which typically has mortality rates up to 80 percent. The model offers enhanced precision in identifying patients most likely to achieve a modified Rankin Scale score of 0-1 at 90 days. This predictive model addresses the significant challenge of patient selection in managing acute vertebrobasilar artery occlusion. Article 4: Insomnia and Incident Cardiovascular Disease in US Hispanic/Latino Adults: Results From HCHS/SOL. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717941 Summary: This study analyzed data from 3635 Hispanic/Latino adults and found a significant association between insomnia and incident cardiovascular disease. Insomnia was assessed using the Women’s Health Initiative Insomnia Rating Scale, evaluating group status, symptom severity, specific symptom dimensions, and sleep duration at baseline. The results demonstrated that insomnia is an independent cardiovascular risk factor in this specific demographic. This highlights the importance of screening for and managing insomnia to potentially mitigate cardiovascular risk in Hispanic/Latino populations. Article 5: Safety and Efficacy of Early Aspirin Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT): Rationale and Design of a Multicenter, Randomized, Placebo-Controlled Clinical Trial. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717940 Summary: The TREND-IVT trial is a multicenter, randomized,...
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  • AI Links Dental Care to Higher Heart Risk 02/23/26

    AI Links Dental Care to Higher Heart Risk 02/23/26
    Feb 23 2026
    Welcome to Cardiology Today – Recorded February 23, 2026. This episode summarizes 5 key cardiology studies on topics like electrocardiography and adverse outcomes. Key takeaway: AI Links Dental Care to Higher Heart Risk. Article Links: Article 1: Interferon-γ-Responsive Microglia-Derived Extracellular Vesicles Inhibited Neurogenesis After Stroke via MicroRNA-199a-5p/SIRT1 Axis. (Journal of the American Heart Association) Article 2: Annual Trends in Risk Factor Control Status at the Time of Ischemic Stroke in South Korea. (Journal of the American Heart Association) Article 3: Short-Term Exposure to Ambient Ozone and Fine Particulate Matter and Its Components Increases the Risk of In-Hospital Adverse Outcomes in Patients With Acute Myocardial Infarction: A Time-Stratified Case-Crossover Study. (Journal of the American Heart Association) Article 4: Cold Waves and Elevation Strengthen the Association of Particulate Matter Exposure With Hypertension Prevalence: A Large Multiregional Study in China. (Journal of the American Heart Association) Article 5: Inadequate Preventive Dental Care Is Associated With Higher Cardiovascular Risk Identified by ECG-Based Artificial Intelligence Algorithms. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/ai-links-dental-care-to-higher-heart-risk-02-23-26/ Featured Articles Article 1: Interferon-γ-Responsive Microglia-Derived Extracellular Vesicles Inhibited Neurogenesis After Stroke via MicroRNA-199a-5p/SIRT1 Axis. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717953 Summary: This study found that interferon-gamma-responsive microglia-derived extracellular vesicles inhibited neurogenesis after stroke. This inhibition occurred via the microRNA-199a-5p/SIRT1 axis, revealing a specific molecular mechanism. The data demonstrated a pathway contributing to impaired neurological function recovery following cerebral ischemia. This new understanding identifies a potential therapeutic target to enhance neurogenesis and improve patient outcomes after stroke. Article 2: Annual Trends in Risk Factor Control Status at the Time of Ischemic Stroke in South Korea. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717952 Summary: This study evaluated annual trends in the control of major risk factors at the time of ischemic stroke in South Korea from 2011 to 2022. Researchers analyzed data from a nationwide registry, focusing on hypertension, diabetes, and dyslipidemia. The findings from this real-world assessment identified specific areas where current prevention guidelines for ischemic stroke need greater clinical attention. This work helps improve early stroke outcomes by highlighting gaps in risk factor management. Article 3: Short-Term Exposure to Ambient Ozone and Fine Particulate Matter and Its Components Increases the Risk of In-Hospital Adverse Outcomes in Patients With Acute Myocardial Infarction: A Time-Stratified Case-Crossover Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717950 Summary: This study found that short-term exposure to ambient ozone and fine particulate matter with a diameter of less than or equal to 2.5 micrometers increased the risk of in-hospital adverse outcomes for patients with acute myocardial infarction. The time-stratified case-crossover study, conducted in Beijing, demonstrated this association between air pollutants and patient morbidity. This data highlights the critical impact of environmental factors on immediate post-infarction prognosis. Clinicians should consider air quality in managing acute myocardial infarction patients. Article 4: Cold Waves and Elevation Strengthen the Association of Particulate Matter Exposure With Hypertension Prevalence: A Large Multiregional Study in China. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717949 Summary: This large multiregional study in China found that cold waves and geographic elevation strengthened the association of particulate matter exposure with hypertension prevalence. Researchers analyzed data from 27000 adults, demonstrating that these co-occurring environmental stressors exacerbate the known risk of air pollution for hypertension. The data revealed significant interactive effects between long-term particulate matter exposure, cold weather, and altitude. This understanding is crucial for public health strategies addressing hypertension in varied geographical and climatic conditions. Article 5: Inadequate Preventive Dental Care Is Associated With Higher Cardiovascular Risk Identified by ECG-Based Artificial Intelligence Algorithms. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717947 Summary: This study found that inadequate preventive dental care was associated with a higher ...
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  • Empagliflozin Cuts Brain Injury After Cardiac Arrest 02/22/26

    Empagliflozin Cuts Brain Injury After Cardiac Arrest 02/22/26
    Feb 22 2026
    Welcome to Cardiology Today – Recorded February 22, 2026. This episode summarizes 5 key cardiology studies on topics like hypotension and Coronary embolism. Key takeaway: Empagliflozin Cuts Brain Injury After Cardiac Arrest. Article Links: Article 1: Pelacarsen and lipoprotein(a) apheresis in secondary prevention: the Lp(a)FRONTIERS APHERESIS trial. (European heart journal) Article 2: Three-dimensional echocardiography for valvular heart disease: clinical implications. (European heart journal) Article 3: Etiology, Management, and Outcomes of Society for Cardiovascular Angiography and Interventions Stage B Cardiogenic Shock. (Circulation. Heart failure) Article 4: Atrial Fibrillation Versus Nonatrial Fibrillation Coronary Embolism: A Multicenter Study. (Journal of the American Heart Association) Article 5: Empagliflozin Attenuates Global Cerebral Ischemic Injury After Cardiac Arrest Through Enhancing Ketone Body Oxidative Metabolism in Rats. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/empagliflozin-cuts-brain-injury-after-cardiac-arrest-02-22-26/ Featured Articles Article 1: Pelacarsen and lipoprotein(a) apheresis in secondary prevention: the Lp(a)FRONTIERS APHERESIS trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41721795 Summary: Lipoprotein apheresis (L. A.) is the only approved treatment for patients with elevated lipoprotein(a). The Lp(a)FRONTIERS APHERESIS trial established a treatment protocol where adult patients with lipoprotein(a) levels greater than 60 milligrams per deciliter and established cardiovascular disease were randomized. These patients had previously undergone frequent lipoprotein apheresis sessions. Participants received either 80 milligrams of pelacarsen or placebo every 4 weeks for 52 weeks, continuing weekly lipoprotein apheresis sessions. Article 2: Three-dimensional echocardiography for valvular heart disease: clinical implications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41721505 Summary: Three-dimensional echocardiography has emerged as an essential tool in evaluating and managing valvular heart disease. This imaging modality offers superior accuracy and detailed visualization when used with both transthoracic and transesophageal approaches. Its importance has been particularly underscored in guiding transcatheter valve interventions for high-risk or inoperable patients. The technology enables precise assessment of valvular anatomy, directly improving patient management. Article 3: Etiology, Management, and Outcomes of Society for Cardiovascular Angiography and Interventions Stage B Cardiogenic Shock. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41711037 Summary: This study evaluated adult patients with Society for Cardiovascular Angiography and Interventions (S. C. A. I.) stage B cardiogenic shock from 2017 to 2022 across a six-hospital system. The definition for S. C. A. I. B cardiogenic shock included hypotension, specifically systolic blood pressure less than or equal to 90 mmHg or mean blood pressure less than or equal to 65 mmHg, or hypoperfusion indicated by lactate levels between 2 to 5 milliequivalents per liter. Cardiac arrest, use of circulatory support, and noncardiac etiologies were explicitly excluded from this definition. This framework provides a basis for understanding and studying this patient population. Article 4: Atrial Fibrillation Versus Nonatrial Fibrillation Coronary Embolism: A Multicenter Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717963 Summary: This multicenter study included 489 patients diagnosed with coronary embolism across 10 hospitals, using Shibata criteria for diagnosis. The study found that 241 patients, representing 49 percent of the cohort, had atrial fibrillation-related coronary embolism. Researchers identified distinct characteristics between atrial fibrillation-related and non-atrial fibrillation coronary embolism patient groups. This research provides initial comparative data on this underrecognized cause of acute myocardial infarction. Article 5: Empagliflozin Attenuates Global Cerebral Ischemic Injury After Cardiac Arrest Through Enhancing Ketone Body Oxidative Metabolism in Rats. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717961 Summary: This study demonstrated that empagliflozin attenuates global cerebral ischemic injury following cardiac arrest in rats. The observed neuroprotective effects were achieved through the enhancement of ketone body oxidative metabolism. Researchers utilized a model where 206 adult male Sprague-Dawley rats were subjected to cardiac arrest via ventricular fibrillation and subsequent cardiopulmonary resuscitation. This finding positions empagliflozin as a potential therapeutic agent for reducing neurological deficits ...
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  • Prolonged QT Elevates Recurrent Stroke Risk by 73% 02/21/26

    Prolonged QT Elevates Recurrent Stroke Risk by 73% 02/21/26
    Feb 21 2026
    Welcome to Cardiology Today – Recorded February 21, 2026. This episode summarizes 5 key cardiology studies on topics like venoarterial extracorporeal membrane oxygenation and calcific aortic valve disease. Key takeaway: Prolonged QT Elevates Recurrent Stroke Risk by 73%. Article Links: Article 1: HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance. (Circulation) Article 2: Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis. (European heart journal) Article 3: Temporal Hemodynamic Patterns in Cardiogenic Shock Treated with Isolated PVAD and Combined Therapy with VA-ECMO. (Journal of cardiac failure) Article 4: Prolonged QT interval and risk of recurrent stroke in the Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke (ARCADIA) trial. (Heart (British Cardiac Society)) Article 5: Predictors of Stroke Volume Improvement with AV-Optimised Conduction System Pacing in Patients with AV Dromotropathy. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/prolonged-qt-elevates-recurrent-stroke-risk-by-73-02-21-26/ Featured Articles Article 1: HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717681 Summary: An antibody-drug conjugate targeting high endothelial venules in lymph nodes has been shown to promote long-term cardiac allograft acceptance. This therapeutic strategy leverages the crucial role of high endothelial venules in mediating naive T cell entry into lymph nodes, a vital step for transplant acceptance under costimulatory blockade. The conjugate specifically targets a glycoprotein containing 6-sulfo sialyl Lewis X on these venules, which forms the binding site for L-selectin on naive T cells. This approach offers a novel mechanism to prevent immune rejection in heart transplant recipients. Article 2: Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41721439 Summary: In this observational study of up to 6598 participants, lipoprotein(a) and L. D. L. cholesterol were confirmed as causally linked to aortic valve calcium and aortic stenosis. The analysis found that aspirin use was not associated with incident aortic valve calcium or aortic stenosis. This lack of association held true regardless of baseline lipoprotein(a) or L. D. L. cholesterol levels. The data suggests that aspirin does not mitigate the risk of calcific aortic valve disease in individuals with high lipoprotein(a). Article 3: Temporal Hemodynamic Patterns in Cardiogenic Shock Treated with Isolated PVAD and Combined Therapy with VA-ECMO. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41720453 Summary: This study described the temporal hemodynamic patterns observed in cardiogenic shock patients receiving either an isolated microaxial flow pump or combined therapy with venoarterial extracorporeal membrane oxygenation. Hemodynamic indices were analyzed from pre-device installation, post-installation, and 24 hours after, up to device explantation, using data from the U. N. L. O. A. D. E. R. S.-P. VAD Registry. The study characterized these hemodynamic trends for both treatment groups. Hospital survival was also analyzed in relation to these patterns, providing comparative data on mechanical circulatory support strategies in cardiogenic shock. Article 4: Prolonged QT interval and risk of recurrent stroke in the Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke (ARCADIA) trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41720625 Summary: A secondary analysis of the A. R. C. A. D. I. A. trial found that a prolonged Q. T. interval independently predicted an increased risk of recurrent stroke or systemic embolism in patients with cryptogenic stroke and atrial cardiopathy. This association held true for both the apixaban arm, with a hazard ratio of 1.70 (95 percent confidence interval 1.05-2.75), and the aspirin arm, showing a hazard ratio of 1.76 (95 percent confidence interval 1.05-2.95). The overall adjusted hazard ratio for this risk was 1.73 (95 percent confidence interval 1.25-2.38), with no significant interaction between Q. T. interval prolongation and treatment assignment (P value 0.95). This data demonstrates that prolonged Q. T. interval is an independent predictor of recurrent stroke regardless of antithrombotic treatment. Article 5: Predictors of Stroke Volume Improvement with AV-Optimised Conduction System Pacing in Patients with AV Dromotropathy. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41711207 Summary: This study identified electrocardiographic and echocardiographic predictors of acute stroke volume improvement ...
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  • N. L. R. Trajectory Guides Heart Failure Risk 02/20/26

    N. L. R. Trajectory Guides Heart Failure Risk 02/20/26
    Feb 20 2026
    Welcome to Cardiology Today – Recorded February 20, 2026. This episode summarizes 5 key cardiology studies on topics like acute decompensated heart failure and prostate cancer. Key takeaway: N. L. R. Trajectory Guides Heart Failure Risk. Article Links: Article 1: Tropical cyclones and acute coronary syndromes: a Chinese nationwide study. (European heart journal) Article 2: Wisdom of the Crowd: Ensuring the Justness and Validity of Group Decision-Making in Solid Organ Transplant. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 3: Coronary Plaque Progression After Androgen Deprivation Therapy in Men With Prostate Cancer: A Randomized Clinical Trial. (JAMA cardiology) Article 4: Clinical Factors and Biomarkers During Pregnancy and Risk of Cardiovascular Disease. (JAMA cardiology) Article 5: Discharge Neutrophil-to-Lymphocyte Ratio and Its Trajectory as Predictors of 30-Day Outcomes in Acute Heart Failure. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/n-l-r-trajectory-guides-heart-failure-risk-02-20-26/ Featured Articles Article 1: Tropical cyclones and acute coronary syndromes: a Chinese nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41705661 Summary: The association between tropical cyclone exposure and acute coronary syndrome incidence is a critical area of cardiovascular research, particularly within developing nations such as China. This line of inquiry demonstrates that environmental stressors are important, albeit understudied, contributors to acute coronary syndromes. Understanding these links provides a framework for developing targeted public health interventions and early warning systems in vulnerable regions. This research highlights the clinical importance of considering environmental factors in cardiovascular event prediction. Article 2: Wisdom of the Crowd: Ensuring the Justness and Validity of Group Decision-Making in Solid Organ Transplant. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41713791 Summary: Group decision-making in solid organ transplant is critical for complex, high-stakes decisions, improving quality by pooling information and minimizing individual cognitive biases. However, this process can lead to poor outcomes if not properly implemented, especially given that many health professionals lack formal training in such methodologies. Effective group decision-making requires structured approaches to ensure justness and validity, thereby enhancing patient and societal outcomes. This underscores the need for formalized training in transplant decision protocols. Article 3: Coronary Plaque Progression After Androgen Deprivation Therapy in Men With Prostate Cancer: A Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706486 Summary: Androgen deprivation therapy for men with prostate cancer carries a significant association with cardiovascular morbidity. A key clinical question revolves around whether gonadotropin-releasing hormone agonists or antagonists differ in their impact on coronary atherosclerosis progression. This area of research demonstrates concerns about accelerated coronary atherosclerosis in patients receiving androgen deprivation therapy. Understanding these differential effects is crucial for optimizing treatment strategies and mitigating cardiovascular risks in this patient population. Article 4: Clinical Factors and Biomarkers During Pregnancy and Risk of Cardiovascular Disease. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706460 Summary: Pregnancy serves as a natural and informative cardiovascular stress test, offering a crucial window to assess a woman’s long-term cardiovascular disease risk. Clinical measures and biomarkers obtained during pregnancy have demonstrated potential in identifying women at elevated risk for future cardiovascular disease. Leveraging these insights from pregnancy encounters can inform tailored risk stratification and preventive strategies for women globally. This approach offers a novel pathway for early identification and intervention to mitigate the leading cause of death among women. Article 5: Discharge Neutrophil-to-Lymphocyte Ratio and Its Trajectory as Predictors of 30-Day Outcomes in Acute Heart Failure. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41711242 Summary: The neutrophil-to-lymphocyte ratio, or N. L. R., and its in-hospital trajectory were comprehensively assessed as predictors of 30-day outcomes after acute decompensated heart failure hospitalization. This retrospective cohort study of 6784 discharges confirmed the prognostic value of discharge N. L. R., classified as less ...
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  • Sex Impacts Microaxial Pump Outcomes in Shock 02/19/26

    Sex Impacts Microaxial Pump Outcomes in Shock 02/19/26
    Feb 20 2026
    Welcome to Cardiology Today – Recorded February 19, 2026. This episode summarizes 5 key cardiology studies on topics like interventricular septum and right bundle branch block. Key takeaway: Sex Impacts Microaxial Pump Outcomes in Shock. Article Links: Article 1: Sex-Specific Microaxial Flow Pump Use and Outcomes in Infarct-Related Cardiogenic Shock in the DanGer Shock Trial. (Journal of the American College of Cardiology) Article 2: Post-certification competencies and cardiovascular care delivery. (European heart journal) Article 3: Conduction disturbances after transcatheter aortic valve implantation. (European heart journal) Article 4: Delirium in cardiovascular medicine. (European heart journal) Article 5: Great debate: drug-coated balloons are preferable to drug-eluting stents for coronary in-stent restenosis. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/sex-impacts-microaxial-pump-outcomes-in-shock-02-19-26/ Featured Articles Article 1: Sex-Specific Microaxial Flow Pump Use and Outcomes in Infarct-Related Cardiogenic Shock in the DanGer Shock Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41222528 Summary: The DanGer Shock trial found that microaxial flow pump use improved outcomes in selected patients with S. T. elevation myocardial infarction and cardiogenic shock. However, the beneficial effect of the microaxial flow pump was observed to be less evident in women compared with men. This secondary analysis determined significant sex differences in baseline characteristics, in-hospital course, and the effectiveness of the microaxial flow pump in S. T. elevation myocardial infarction with cardiogenic shock. This highlights a critical disparity in treatment efficacy based on patient sex. Article 2: Post-certification competencies and cardiovascular care delivery. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41712366 Summary: This analysis emphasizes that while cardiologists achieve core cardiovascular competencies, ongoing training, assessment, and maintenance of post-certification competencies are crucial for effective practice. It shows cardiologists must function as part of a comprehensive multidisciplinary Heart Team across the full spectrum of cardiovascular care. This continuous professional development ensures optimal patient outcomes in the dynamic field of cardiology. These findings reinforce the necessity of lifelong learning beyond initial certification. Article 3: Conduction disturbances after transcatheter aortic valve implantation. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41712363 Summary: Conduction disturbances and permanent pacemaker implantation are among the most common complications observed after transcatheter aortic valve implantation. Studies show that the strongest predictors of these conduction abnormalities include pre-existing right bundle branch block, a short membranous interventricular septum, deep transcatheter heart valve implantation, and the specific transcatheter heart valve type. These findings highlight critical patient and procedural characteristics that significantly influence post-procedural electrical outcomes. Article 4: Delirium in cardiovascular medicine. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41711546 Summary: Delirium is a common neuropsychiatric syndrome frequently observed in cardiovascular medicine, which studies show is associated with prolonged hospitalization, increased mortality, and long-term cognitive decline. Patients undergoing interventional or surgical cardiovascular procedures, such as transcatheter aortic valve replacement, surgical aortic valve replacement, coronary artery bypass grafting, or percutaneous coronary interventions, are particularly vulnerable to its development. These findings underscore the significant impact of delirium on patient outcomes and identify high-risk populations. Article 5: Great debate: drug-coated balloons are preferable to drug-eluting stents for coronary in-stent restenosis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41711522 Summary: Drug-coated balloons have demonstrated efficacy as an alternative to drug-eluting stents in percutaneous coronary interventions, particularly favored for their “leave nothing behind” approach. Recent clinical evidence supports the effectiveness of drug-coated balloons in treating both small vessel disease and bifurcation lesions. This indicates that drug-coated balloons provide a significant therapeutic option for specific coronary artery disease subsets. Transcript Today’s date is February 19, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Sex-Specific Microaxial Flow Pump Use and Outcomes in Infarct-Related Cardiogenic Shock in the DanGer Shock Trial. The DanGer Shock trial found ...
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  • Sirolimus Balloon Challenges Paclitaxel Mortality 02/19/26

    Sirolimus Balloon Challenges Paclitaxel Mortality 02/19/26
    Feb 19 2026
    Welcome to Cardiology Today – Recorded February 19, 2026. This episode summarizes 5 key cardiology studies on topics like mind-body exercise and older adults. Key takeaway: Sirolimus Balloon Challenges Paclitaxel Mortality. Article Links: Article 1: Comparison of Sirolimus- vs Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Artery Disease: The SIRONA Randomized Noninferiority Trial. (Journal of the American College of Cardiology) Article 2: Effect of Baduanjin on Blood Pressure Among Individuals With High-Normal Blood Pressure: A Multicenter, Open-Label, Blinded-Outcome Randomized Controlled Trial. (Journal of the American College of Cardiology) Article 3: Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. (Journal of the American College of Cardiology) Article 4: Mitral Valve Repair for Degenerative MR With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. (Journal of the American College of Cardiology) Article 5: Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients. (Journal of the American College of Cardiology) Full episode page: https://podcast.explainheart.com/podcast/sirolimus-balloon-challenges-paclitaxel-mortality-02-19-26/ Featured Articles Article 1: Comparison of Sirolimus- vs Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Artery Disease: The SIRONA Randomized Noninferiority Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706076 Summary: Paclitaxel-coated balloon angioplasty effectively treats femoropopliteal artery disease; however, an increased mortality risk associated with it remains unresolved. Sirolimus-coated balloon angioplasty offers an alternative antiproliferative drug approach for these interventions. The SIRONA randomized noninferiority trial evaluated sirolimus-coated balloon angioplasty against paclitaxel-coated balloon angioplasty. This comparison determines if sirolimus-coated balloons achieve noninferior primary vessel patency and clinical efficacy with an improved safety profile. Article 2: Effect of Baduanjin on Blood Pressure Among Individuals With High-Normal Blood Pressure: A Multicenter, Open-Label, Blinded-Outcome Randomized Controlled Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706075 Summary: Achieving sustained blood pressure lowering with traditional lifestyle guidance and exercise presents a challenge for individuals with high-normal blood pressure. Baduanjin, a traditional Chinese mind-body exercise, serves as a non-pharmacological therapeutic approach under investigation for this population. A multicenter, open-label, blinded-outcome randomized controlled trial assessed Baduanjin’s short-term impact on ambulatory blood pressure and its long-term effects. This study evaluated participants aged 40 years or older who presented with systolic blood pressure of 130 to 139 mmHg or diastolic blood pressure of 85 mmHg or higher. Article 3: Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706074 Summary: M. 2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. Intensifying wildfires in a warming climate result in prolonged exposure to smoke-derived fine particulate matter (P. M. 2.5), which poses significant health risks. The cardiovascular impacts of long-term cumulative exposure to wildfire smoke P. M. 2.5, particularly in older adults, represent an area of critical clinical investigation. This population-based cohort study analyzed associations between long-term cumulative exposure to wildfire smoke P. M. 2.5 and first cardiovascular disease hospitalizations. The research focused on U.S. Medicare beneficiaries, examining the effects on cardiovascular health in this vulnerable population. Article 4: Mitral Valve Repair for Degenerative MR With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706073 Summary: R. With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. Recurrent mitral regurgitation degree serves as a key indicator for the quality of mitral valve repair for degenerative mitral regurgitation. This multicenter study evaluated 2-year survival and mitral regurgitation recurrence following mitral valve repair in ...
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