The Epigenetics Revolution

From finding a spouse to finding a parking spot, from organizing one's inbox to understanding the workings of human memory, Algorithms to Live By transforms the wisdom of computer science into strategies for human living.

Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.

Genome unravels the secrets of human nature without the usual reams of technical jargon. It shows outstanding breakthroughs in gene research, how we've gone from knowing almost nothing to knowing almost everything, and how our genes reveal more about our past, our evolution, and even our minds. Every important event in human history is written into our genes, whether it happened four billion or a few hundred years ago. All you need to know is where to look.

How can a blind person learn to see with her tongue or a deaf person learn to hear with his skin? What does a baby born without a nose tell us about our sensory machinery? Might we someday control a robot with our thoughts? And what does any of this have to do with why we dream? The answers to these questions are not right in front of our eyes; they're right behind our eyes. This book is not simply about what the brain is but what it does. Covering decades of research to the present day, Livewired also presents new findings from Eagleman's own research.

For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98 percent of the human genome - were dismissed as ‘junk’. But in recent years researchers have discovered that variations in this ‘junk’ DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. 

Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands to rethink their beliefs about life.

Just 45 years ago, the age of gene modification was born. Researchers could create glow-in-the-dark mice, farmyard animals producing drugs in their milk, and vitamin-enhanced rice that could prevent half a million people going blind every year. But now GM is rapidly being supplanted by a new system called CRISPR or "gene editing". Using this approach, scientists can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago.

The Gene is the story of one of the most powerful and dangerous ideas in our history, from best-selling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master code that makes and defines humans, that governs our form and function. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856, where a monk stumbles on the idea of a 'unit of heredity'.

This is the story of how your life shapes your brain and how your brain shapes your life. Locked in the silence and darkness of your skull, the brain fashions the rich narratives of your reality and your identity. Join renowned neuroscientist David Eagleman for a journey into the questions at the heart of our existence. What is reality? Who are 'you'? How do you make decisions? Why does your brain need other people? How is technology poised to change what it means to be human?

We are capable of savage acts of violence but also spectacular feats of kindness: is one side of our nature destined to win out over the other? Every act of human behaviour has multiple layers of causation, spiralling back seconds, minutes, hours, days, months, years, even centuries, right back to the dawn of time and the origins of our species. In the epic sweep of history, how does our biology affect the arc of war and peace, justice and persecution? How have our brains evolved alongside our cultures?

In the best-selling, prize-winning A Short History of Nearly Everything Bill Bryson achieved the seemingly impossible by making the science of our world both understandable and entertaining to millions of people around the globe. Now he turns his attention inwards to explore the human body, how it functions and its remarkable ability to heal itself. Full of extraordinary facts and astonishing stories, The Body: A Guide for Occupants is a brilliant, often very funny attempt to understand the miracle of our physical and neurological makeup.

In this absorbing and frequently contentious book, Roger Penrose puts forward his view that there are some facets of human thinking that can never be emulated by a machine. The book's central concern is what philosophers call the "mind-body problem". Penrose examines what physics and mathematics can tell us about how the mind works, what they can't, and what we need to know to understand the physical processes of consciousness.

The Blind Watchmaker, knowledgably narrated by author Richard Dawkins, is as prescient and timely a book as ever. The watchmaker belongs to the 18th-century theologian William Paley, who argued that just as a watch is too complicated and functional to have sprung into existence by accident, so too must all living things, with their far greater complexity, be purposefully designed. Charles Darwin's brilliant discovery challenged the creationist arguments; but only Richard Dawkins could have written this elegant riposte.

Time is a mystery that does not cease to puzzle us. Philosophers, artists and poets have long explored its meaning while scientists have found that its structure is different from the simple intuition we have of it. From Boltzmann to quantum theory, from Einstein to loop quantum gravity, our understanding of time has been undergoing radical transformations. Time flows at a different speed in different places, the past and the future differ far less than we might think, and the very notion of the present evaporates in the vast universe.

By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only 24, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries.